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BDNF 激活 ERK1/2 通路:改善老龄卵母细胞质量的新希望
MSC-sec 改善老龄小鼠卵母细胞质量 :在体外成熟实验中,与年轻小鼠卵母细胞相比,老龄小鼠卵母细胞的第一极体(PB1)排出率较低。添加人脐带间充质干细胞分泌组(hUC-MSC-sec)后,PB1 排出率显著增加,而添加成纤维细胞分泌组(Fib-sec)则无明显变化。同时,hUC-MSC-sec 处理减少了老龄小鼠卵母细胞的纺锤体异常和非整倍体率,表明 MSC-sec ...
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