这表明蛋白酶体抑制会引起 CRC 细胞 DNA 甲基化谱的显著变化。 蛋白酶体抑制通过使 mTOR 失活减弱 DNMT1 和 DNMT3B 的翻译：DNA 甲基化由 DNA 甲基转移酶（DNMTs）催化和维持，研究发现 MG132 能显著下调 DNMT1 和 DNMT3B 的表达，且这种下调具有剂量和时间依赖性，其他 PIs ...

上海交通大学在《Nature Communications》上发表了TGFβ- SMAD信号和DNA甲基化的逐步模式调节原始到启动的多能性和分化的研究成果，影响因子14.7。本研究中ATAC-seq检测及部分数据分析工作均由上海派森诺生物科技股份有限公司完成。 01、研究背景 TGF-β信号通路在小鼠 ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Rats in the mTBI + PTSD group also exhibited higher hippocampal DNMT3b protein expression compared with those in the PTSD group. Conclusion: In conclusion, our results demonstrated that mTBI increases ...

Frontiers Science Center for Molecular Design Breeding of the Ministry of Education, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding; Key ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of ...