研究人员探究伊沙伏康唑（ISCZ）对他克莫司（TAC）浓度影响，发现 CYP3A5 多态性有作用，需监测 TAC 等水平。 ### 伊沙伏康唑与他克莫司药物相互作用研究解读 在医学领域，肾移植手术为许多终末期肾病患者带来了新的希望。然而，长期的免疫抑制治疗却像一把 ...

Background: Previous studies have reported a reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (rs 776746). However, information regarding Colombian liver ...

One hundred sixty-two (162) patients were enrolled. The inclusion criteria were as follows: 1) patients with histologically confirmed BC, 2) in adjuvant treatment with 20 mg of tamoxifen (Novadex®) ...

Large interethnic differences in allele frequencies exist for the functional CYP3A5*1 allele. CYP3A5 is a metabolizing enzyme expressed in the intestine, liver and kidney. CYP3A5 enzymatic ...