Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

为解决 CAR-NK 细胞疗法面临的挑战，研究人员总结 2024 ASH 年会成果，发现其在多疾病治疗有潜力。 在人体的免疫系统中，自然杀伤细胞（NK 细胞）就像是一群训练有素的 “免疫特种兵”，时刻警惕着癌细胞的出现。它们无需提前 “认识” 癌细胞，就能凭借自身 ...

为解决慢性髓性白血病（CML）对 BCR-ABLi 耐药难题，俄罗斯科学院基因生物学研究所研究人员开展 CDK8/19 抑制对 CML 细胞影响的研究。发现 CDK8/19i 可增敏 BCR-ABLi，加速癌细胞死亡。极具科研价值，推荐一读！ 俄罗斯科学院基因生物学研究所（Institute of Gene Biology ...

This is an important study providing compelling evidence that the Mediator kinase module mediates an elevated inflammatory response, manifested by heightened cytokine levels, associated with Downs ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the immune system. NK cells recognize target ...