人类NK细胞的常见表面标志物为CD56和CD16，而小鼠NK细胞则表达NK1.1和CD49b（DX5）。需要注意的是，T细胞亚群中的NKT细胞与NK细胞在表型和功能上有相似之处，NKT细胞同时表达CD16、CD56、NK1.1、CD49b，并能产生颗粒酶。因此，在进行NK细胞分型时，通常需要通过CD3阴性 ...

以往用于区分 NK 细胞和 ILC1s 的传统标记物，如 Eomes、CD49b、CD200R 等，由于在不同细胞状态下表达不稳定，无法准确区分这两种细胞。因此，寻找一种可靠的标记物来精准划分 NK 细胞和 ILC1s，成为免疫学领域亟待解决的重要问题。 为了攻克这一难题，来自美国 ...

Mucosal-associated invariant T (MAIT) cells belong to a family of innate-like T cells that bridge innate and adaptive immunities. Although MAIT cells have been implicated in tumor immunity, it ...

Background: Human papillomavirus-positive (HPV+) cervical cancers are highly heterogeneous in molecular and clinical features. However, the molecular classification of HPV+ cervical cancers remains ...

In studies in murine models, active suppression by IL-10-secreting Foxp3 regulatory T cells (Tregs) has emerged as an essential mechanism in colon homeostasis. However, the role of the equivalent ...

The immune system has ‘T’ cells that recognize when the body is infected with a virus or bacterium and mount an immune response that is targeted to that microbe. They can also find and eliminate ...