Background GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear. Objective We aimed to investigate ...

Seminal work by Fiona Powrie in 1993 described two populations of T cells that can induce or protect immunodeficient mice from chronic colitis following adoptive transfer of T cells based on the ...

In Rag-1 KO mice reconstituted with CD4 CD45RB high T cells, we assessed the treatment effect of PD-L1-Fc protein on the development of colitis. Results Administration of Ad/PD-L1-Fc significantly ...

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...