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异二聚体AHR-ARNT复合物的配体依赖性激活的结构基础
配体结合后,AHR 从细胞质转移到细胞核,与芳烃受体核转运蛋白(aryl hydrocarbon receptor nuclear translocator,ARNT)形成具有转录活性的复合物,该复合物可与 DNA 结合并启动基因表达程序,这些程序涉及细胞解毒途径和免疫反应。在本研究中,山东大学微生物技术 ...
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