9p21.3染色体是一个与罕见常染色体显性癌症易感综合征相关的基因座，其特征为早发性黑色素瘤及广谱神经系统肿瘤。该核心区域中两个主要抑癌基因——细胞周期依赖性激酶抑制因子2A和2B（CDKN2A与CDKN2B）以及长链非编码RNA ANRIL常发生共缺失。本文报道一例孕妇 ...

The management of retinoblastoma, the most common intraocular malignancy in children, has changed drastically over the last decade. Landmark developments in local drug delivery, namely, safer ...

Relapsed/refractory neuroblastoma is a type of malignant solid tumor with a very poor prognosis in children. Its pathogenesis is complex, involving multiple molecular pathways and genetic alterations.

Hall et al. show that p53 can influence the timing of virus-induced CPE at a single multiplicity of infection in cancer cell lines. Is this conclusion at odds with data from other groups, or with ...