三、研究结果：关键 miRNA “浮出水面” 综上所述，该研究发现了轻度 COVID-19 患者血清中 miRNA 的独特表达模式。miR-27a-5p 的高表达可能对重症疾病具有保护作用；miR-1246 的下调与有效的抗病毒细胞宿主防御相关；miR-21-5p 表达降低可能预防肺纤维化的发展 ...

研究人员探索 hsa-miR-27a-3p 对帕金森病（PD）信号通路的调节作用，发现其可改善细胞状态，有治疗潜力。 帕金森病（Parkinson's disease，PD）是一种复杂的神经退行性疾病，其特征为多巴胺能神经元缺失和路易小体的存在。除了典型的运动症状外，PD 还涉及显著的 ...

据国际癌症研究机构（IARC）发布的GLOBOCAN2022年数据显示，肺癌在全球癌症发病率和死亡率中位居第一[1]。大家都知道吸烟是肺癌的主要风险因素但相关研究发现肺癌患者中53%的女性和15%的男性均无吸烟史[2]而你不知道的是厨房里藏着一个“危 ...

miR-21：miR-21的过表达能够降低TE-1细胞对顺铂的敏感性，而抑制miR-21则增强其敏感性[6]。 miR-27a：miR-27a通过靶向KRAS抑制TE-1细胞的增殖和侵袭[10]。 CBP（Cyclic AMP Response Element-Binding Protein）的过表达能够显著抑制TE-1细胞的增殖、侵袭和迁移能力，提示其作为治疗靶点 ...

UFC and Bellator veteran Frank Mir’s comeback with the GFL has been put on hold. That’s because early Monday morning, Mir revealed on Instagram that he recently “underwent an emergency spinal fusion ...

MiRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally contributing to the development of different diseases including cancer. The miR-200 family consists of five ...

Frank Mir’s proposed Global Fight League debut is likely in jeopardy after he recently underwent emergency spinal surgery. Advertisement The Ultimate Fighting Championship and Bellator MMA ...

Mufti Shah Mir, Muslim scholar who helped Pakistan's ISI in abducting Kulbhushan Jadhav from Iran, shot dead by unknown men. Mufti Shah Mir was killed by unknown gunmen in Balochistan. Mir was ...

Background: MiR-136 is abnormally expressed in many types of metastatic tumors and is closely associated with tumor cell proliferation, apoptosis, invasion, and metastasis, indicating its important ...

The most discriminatory miRNA, with the highest |fold change|, was miR-451a, which regulates the expression of the drug-transporter protein P-glycoprotein, potentially promoting paclitaxel resistance.

黄芪-丹参汤可改善压力过载诱导的心力衰竭大鼠心脏功能、抑制心肌重塑，其机制与抑制衰竭心脏心包脂肪组织来源的细胞外囊泡中miR-27a-3p、激活 ...