然而，柚皮苷对宫颈癌的具体作用机制仍有待深入探讨。PI3K/Akt/mTOR通路是一条重要的细胞信号传导通路，涉及多种细胞刺激的激活，其功能在肿瘤的发生、进展和药物反应中起着至关重要的作用。通过靶向PI3K/Akt/mTOR通路的药物，已在多个研究中被证实可以抑制肿瘤的发展。因此，深入研究柚皮苷在宫颈癌细胞中对PI3K/Akt/mTOR通路的影响，不仅为宫颈癌的临床治疗提供了新的思路，也为开发新的 ...

举个栗子，研究发现柚皮苷可以通过多靶点、多途径和多层次的方式调节相关的失调信号级联反应，从而阻断肿瘤细胞周期、抑制肿瘤细胞增殖、调节自噬、逆转耐药性，并增强化疗药物的敏感性。这些作用机制使得柚皮苷成为了一种非常有潜力的天然抗肿瘤化合物。

为探究胡椒碱对在癌症发展中起关键作用的 mTOR 蛋白的影响，研究人员开展了相关研究。通过分子对接、动态模拟、MTT 和划痕实验，发现胡椒碱能与 mTOR 结合，抑制结肠癌细胞活力和迁移，有望用于癌症治疗。 胡椒碱（Piperine）是黑胡椒（Piper nigrum）中的一种 ...

骨肉瘤（OS）治疗中，顺铂（DDP）单药疗效不佳且副作用大。为解决此问题，研究人员开展了豆蔻（CAR）与 DDP 联合治疗 OS 的研究。结果显示，二者联合可协同抑制 OS 细胞生长，机制与 mTOR 介导的自噬有关，这为 OS 治疗提供了新策略。

Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

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However, anti-inflammatory mechanisms targeting IL-1β release in cardiac cells have not been investigated. mTOR is a key regulator of protein metabolism, including autophagy and proteasome activity.

The PI3K/AKT/mTOR (PAM) signaling pathway is a classical pathway that is aberrantly activated in cancer cells and promotes the tumorigenesis, metastasis, resistance to castration therapy, ...

Chondrocyte senescence was evaluated by senescence-associated β-galactosidase (SA-β-gal) staining. The PI3K inhibitor LY294002 and the PI3K agonist 740Y-P were used to investigate whether ...

Emerging evidence suggests a role for PI3K/mTOR signalling in the pathology of organ fibrosis. The aim of this study was to delineate PI3K/mTOR signalling in response to TGF-β 1 stimulation of primary ...