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Vanishing White Matter Disease (VWMD) affects brain function due to reduced eIF2B activity. New research uncovers how cells ...

在生物体内，蛋白质合成的调控对细胞稳态至关重要，整合应激反应（ISR）在此过程中意义重大。但 eIF2B 活性降低与经典 ISR（c-ISR）的关系尚不明确。研究人员开展了关于哺乳动物 ISR 可塑性的研究，发现了分裂 ISR（s-ISR），研究成果发表在《Nature》杂志上 ...

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The South San Francisco biotech announced that eIF2B agonist DNL343 was unable to slow disease progression or increase survival compared to placebo at 24 weeks in the study, conducted at Sean M ...

both eIF2B agonists, in failing to slow disease progression in the study. There may be a silver lining, however, as two of them – pridopidine and CNM-Au8 – showed signs of activity on measure ...

2025-03-23报道，近日，中国医学科学院肿瘤医院王洁、白桦等研究者在Signal Transduction and Targeted ...

Lysosomal dysfunction is emerging as a common pathogenic mechanism underlying normal ageing and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by mild lysosomal ...