本研究针对多发性骨髓瘤(MM)患者对一线药物来那度胺(LEN)的获得性耐药机制展开探索。南京第二医院团队发现转录因子YY1通过结合AKR1C3启动子区激活其表达，进而激活Hedgehog信号通路，促进糖酵解代谢重编程，最终导致LEN耐药。该研究揭示了YY1-AKR1C3-Hedgehog轴在MM ...

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Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bioenergetic requirements of muscle stem ...

For input samples, 20µg whole cell lysate was similarly denatured as IP samples. Proteins were separated in SDS-polyacrylamide gel and transferred onto nitrocellulose membrane (Amersham Protran, ...

Background: The diagnosis and treatment of pancreatic adenocarcinoma (PAAD) remain clinically challenging, and new molecular markers for prognostic assessment and targeted therapy are urgently needed.