本研究针对多发性骨髓瘤(MM)患者对一线药物来那度胺(LEN)的获得性耐药机制展开探索。南京第二医院团队发现转录因子YY1通过结合AKR1C3启动子区激活其表达，进而激活Hedgehog信号通路，促进糖酵解代谢重编程，最终导致LEN耐药。该研究揭示了YY1-AKR1C3-Hedgehog轴在MM ...

You can get a new IP address using several techniques. Here's how to change your IP address with a VPN, a proxy server and other methods. Moe enjoys making technical content digestible and fun.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bioenergetic requirements of muscle stem ...