CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, with activation of the IRE1α-XBP1 pathway that ...

Treatment of mice with tunicamycin (Tm) (an ER stress inducer) increased PHLDA3 expression in the liver. X box-binding protein-1 (Xbp1) was newly identified as a transcription factor responsible for ...

这种膜环境变化导致内质网钙离子浓度下降17%，触发未折叠蛋白反应（UPR）的IRE1-XBP1信号轴激活。实验显示，外源性补充鞘磷脂能恢复膜流动性并阻断UPR激活，这为靶向膜物理特性的治疗策略提供了理论依据。 这种脂质介导的应激传递机制具有跨器官普适性 ...

同时，对微生物防御和粘液分泌至关重要的潘氏细胞和杯状细胞，一旦功能出现障碍，就与UPR缺陷密切相关，这会导致菌群失调和炎症反应加剧。 另外，X - box结合蛋白1（XBP1）作为一种由IRE1途径激活的转录因子，在维持IEC功能方面起着举足轻重的作用。实验 ...

PDIA6 deletion may impair both the UPR and proinsulin trafficking; Defective proinsulin trafficking could hinder proinsulin folding in the ER, (6) Inhibition of the IRE1α-XBP1 pathway deregulates PDI ...

1 Department of Medicine, Division of Gastroenterology & Hepatology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK 2 Wellcome Trust PhD Programme for Clinicians, Cambridge Institute ...

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of type 2 diabetes and cardiovascular disease. These include abdominal obesity ...