在口腔健康领域，研究人员们最近取得了一项引人注目的突破。首都医科大学口腔健康北京实验室的王松灵院士团队，在国际学术期刊《Cell Reports》上发表相关研究，阐明了人类早期牙齿发育的细胞和分子机制。这项研究系统绘制了牙齿发育的细胞图谱，揭示了牙源性干细胞如何通过牙上皮的动态信号进行分化。

该研究运用单细胞RNA测序、空间转录组学和分泌组分析等先进技术，对人类胎儿9-15周孕龄牙齿样本进行全面分析，成功构建了人类牙齿早期发育的时空图谱，并精确鉴定出多种具有特定基因表达谱和空间定位的上皮细胞亚群。研究发现，在牙齿发育早期，上皮细胞作为多个关键信号通路的主要信号源，深度参与细胞命运决定、增殖和分化等生物学过程。随着牙齿从蕾状器向钟状期发育，上皮细胞呈现高度异质性，团队精确鉴定出具有独特基 ...

进一步分析发现，DE 分泌的 WNT5B 在调节 DM 牙源性分化中起关键作用。体外实验表明，重组 WNT5B 可促进人原发性 DM 细胞的牙源性分化，敲低 DE 中的 WNT5B 则抑制 DM 细胞的分化。与 WNT5A 相比，WNT5B 对 DM 细胞分化的刺激作用更强。 人类牙齿发育的时空基因表达模型 ...

Zoology is the study of the form and function of animals in the broadest senses of those words. It considers the many roles of animals within the natural world. Discipline of Zoology is one of 4 ...

Osteoarthritis (OA) is the most common degenerative joint disease worldwide, characterized by synovial inflammation, cartilage loss, and reactive hyperplasia of subchondral bone, affecting the quality ...

Click on the following links to see our 3D expression pattern data for the 19 mouse Wnt genes at Theiler stages 15, 17 and 19 (TS15, TS17, and TS19) of mouse development.

Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of ...