为了攻克这一难题，宁夏医科大学的研究人员展开了深入研究。他们将目光聚焦在 Wnt5a 这个神秘的因子上，致力于探究它在 CRPC 中扮演的角色。研究成果发表在了《Journal of Translational Medicine》杂志上。

在口腔健康领域，研究人员们最近取得了一项引人注目的突破。首都医科大学口腔健康北京实验室的王松灵院士团队，在国际学术期刊《Cell Reports》上发表相关研究，阐明了人类早期牙齿发育的细胞和分子机制。这项研究系统绘制了牙齿发育的细胞图谱，揭示了牙源性干细胞如何通过牙上皮的动态信号进行分化。

该研究运用单细胞RNA测序、空间转录组学和分泌组分析等先进技术，对人类胎儿9-15周孕龄牙齿样本进行全面分析，成功构建了人类牙齿早期发育的时空图谱，并精确鉴定出多种具有特定基因表达谱和空间定位的上皮细胞亚群。研究发现，在牙齿发育早期，上皮细胞作为多个关键信号通路的主要信号源，深度参与细胞命运决定、增殖和分化等生物学过程。随着牙齿从蕾状器向钟状期发育，上皮细胞呈现高度异质性，团队精确鉴定出具有独特基 ...

BioAtla is extending its runway beyond key clinical readouts in 1H 2026 by restructuring and realigning resources, which ...

George obtained his doctorate degree from University of Calcutta, India, in 2014. His Ph.D. work involved understanding the role of Wnt5a signaling in macrophage functions. He joined Dr. Chakravarti’s ...

CAB-EpCAM x CAB-CD3 (BA3182) Phase 1 dose-escalation study continues with data readout expected mid-2025; Dose expansion data readout anticipated 1H 2026 Mecbotamab ...

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), especially, exosomes are considered to have diverse therapeutic effects for various significant diseases. MSC-derived exosomes (MSCex) ...

This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...