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细胞自噬发生机制及其检测方式
自噬是一个复杂的细胞降解过程,涉及多个关键步骤:首先,Beclin-1/VPS34 在应激信号的调控下促进吞噬泡的形成;接着,Atg5–Atg12 复合物与 Atg16L 作用,参与吞噬泡的聚合;LC3 蛋白加工并插入吞噬泡膜,随后捕捉靶标进行降解。自噬体通过与溶酶体融合 ...
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