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6 天
综述:髓样细胞参与肿瘤微环境中的肿瘤免疫、转移和代谢
在 B16 黑色素瘤肿瘤模型中,STAT6 诱导 M2 巨噬细胞极化,抑制 M2 巨噬细胞中 TRIM24 的表达,从而诱导免疫抑制性肿瘤微环境的形成。此外,极化的 M2 巨噬细胞通过分泌 IL - 6 增强肿瘤细胞中磷酸甘油酸激酶 1(PGK1)苏氨酸(T)243 位点的磷酸化,抑制这种磷酸化 ...
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