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6 天
颠覆认知!低亲和力T细胞竟是抗癌主力军 免疫治疗策略或将全面重构
深入分析单细胞转录组数据,我们发现了更精细的调控机制。低亲和力T细胞保持着干细胞样记忆特性,其表面CD62L和TCF7的表达水平比高亲和力群体高出4.5倍。这种未完全分化的状态使其具有更强的增殖潜力和组织浸润能力。轨迹分析显示,在免疫检查点阻断治疗 ...
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