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cirm.ca.gov
5 天
MyoD 靶向 TAF3/TRF3 以激活肌生成素转录。
在这里,我们报告了纯化重组系统的开发,以分析 TAF3/TRF3 复合物在肌细胞生成素启动子处指导转录起始的特性。 重要的是,这种新复合物需要取代典型的 TFIID,以重现肌细胞生成素的 MyoD 依赖性激活。 体外和基于细胞的测定确定了介导 MyoD 靶向的共激活子功能 ...
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