2025年3月19日，上海交通大学医学院附属瑞金医院/美国杜克大学的研究团队在期刊《Cell Reports Medicine》上发表了题为“Practical microenvironment classification in diffuse ...

SRBD1的缺失会导致严重的染色体分离缺陷，且这种缺陷与DNA拓扑异构酶IIα（TOP2A）功能障碍导致的姐妹染色单体解连缺陷高度相似。研究发现，SRBD1的活性主要在有丝分裂前期发挥作用，此时染色体正在发生凝缩，而其功能对于后期染色体的正确分离至关重要。

在这样的背景下，寻找有效的生物标志物成为攻克胃癌的关键。生物标志物不仅能助力早期癌症的诊断，还能为预后评估提供重要依据。例如，EIF4G1 可用于预测乳腺癌风险，PMEPA1 则是前列腺癌的潜在标志物和治疗靶点。

Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal ...

2 Tianjin Clinical Research Center for Rheumatic and Immune Diseases, Tianjin, China Correspondence to Dr Wei Wei, Department of Rheumatology and Immunology, Tianjin Medical University General ...

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Transition from normal liver to early ALD was characterised by significant upregulation of proliferation markers (eg, MKI67 and TOP2A); many of these were not significantly DE between AH and early ALD ...

Introduction: Among the various stromal cell types within the tumor microenvironment, cancer-associated fibroblasts (CAFs) emerge as the predominant constituent, exhibiting a diverse array of ...

特发性肺纤维化（idiopathic pulmonary fibrosis，IPF）是最常见的肺纤维化类型之一，以进行性呼吸困难直至呼吸衰竭为主要表现，因其病情不可逆，中位生存期不足5年[1]，常有“类肿瘤疾病”之称[2-3] ， 属中医“肺痹”“肺痿”等范畴。胃食管反流病（gastro-esophageal ...