j-m, Illustration the GSEA analysis analysis of ETCs group and Ipsi-ECs group. Reducing E-pericytes through specific knockout of Tgfbr2 in endothelial cells can impede the recovery of stroke during ...

这些细胞失去正常肝功能，分泌生长分化因子15（GDF15）等因子，通过TGFBR2信号通路与多种肝脏细胞互作。血清GDF15水平与SHGS + 肝细胞负荷和疾病严重程度呈正相关，可作为无创生物标志物（区分F3-4纤维化的AUC=0.85）。 通过筛选2100种化合物，研究人员发现铜螯合 ...

胆管癌（CCA）中的远端胆管癌（dCCA）预后差，神经浸润（PNI）是其重要特征且机制不明。郑州大学研究人员开展单细胞 RNA 测序研究，发现 NE AT 1+ 恶性细胞和 GF AP + 去分化施万细胞（dSCs）促进 dCCA 进展，为治疗提供潜在靶点。郑州大学第一附属医院等机构的研究人员开展了一项重要研究，相关成果发表在《Cell Death and Disease》杂志上。

In addition, two major subtypes of ILC have been identified: an immune-related (IR) subtype and a hormone-related (HR) subtype: The IR subtype is characterized by upregulation of PD-L1 mRNA, PD-1 and ...

来自剑桥大学的研究团队提出了一个名为 Celcomen 的虚拟组织模型，这是首个在空间转录组学分析中具有因果推断可识别性的模型，不仅能估计环境对单个细胞的影响，还能推测单个细胞对其周围环境及整体组织的影响。

Sex differences in the risk factors, diagnosis, treatment, and outcomes of patients with cardiovascular disease have been well described; however, the bulk of the literature has focused on heart ...

Loeys-Dietz syndrome (LDS), caused by mutations in the TGF-β (transforming growth factor-β) signaling cascade, leads to aggressive thoracic aneurysms. While vascular smooth muscle cell (SMC) phenotype ...

MiR-146b has been identified as being overexpressed in human bladder cancer (BCa) and implicated in promoting cancer cell invasion. However, its specific involvement in BCa cell growth remains unclear ...

[Analysis of a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing]. [Discussion on the status quo and solutions to the prevention and ...