Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex ... cGAMP has been shown by the Zhijian Chen lab to bind the signaling protein STING with ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

"There's been millions of dollars invested in drugs that activate and boost the STING pathway to fight cancer ... may actually benefit from STING inhibition," said Bakhoum.

"By activating the STING pathway, the drug promotes a robust anti ... SCLC patients when lurbinectedin was combined with the PD-L1 inhibitor atezolizumab (Tecentriq). "These promising results ...

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

In addition, research is focused on protein-RNA complexes mediating the piRNA pathway (with Julius Brennecke, IMBA-Austria), on identification and characterization of small molecule inhibitors ...