Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...

在这个快节奏的时代，压力似乎成了生活中的常客。科研工作中的挑战、生活中的琐事、社会环境的变化，让我们压力倍增。前沿研究表明，长期暴露于慢性压力之下，其影响远不止于心理层面的紧张与内耗，更在微观与宏观层面，悄然重塑着大脑结构与功能，影响身体内稳态的平衡 ...

Fatty acids are organic acids with at least one carboxyl (-C(=O)OH, -COOH or -CO2H) group and a long carbon chain that can be joined by double bonds, as in unsaturated fatty acids, or single bonds ...

综合来看，这项研究成果丰硕。研究人员系统地探索了 ESCC 的代谢特征，成功识别出 16 种不同的代谢状态，揭示了 ESCC 微环境中广泛的代谢异质性。通过构建基于代谢状态的分类模型，提出了有效的 ESCC 亚型分类策略，并验证了 4 种亚型在预后上的显著差异。此外，还发现细胞解毒途径的失活与 ESCC 患者的不良预后相关，并且找到了 5 个具有潜在治疗价值的基因。这些发现不仅为深入理解 ESCC ...

Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...

RNA 测序和 Western blot 分析证实，AKF-PD 降低 SREBF1 和 SCD1 表达，激活 AMPK 信号通路，同时增加自噬标记物表达。这说明 AKF-PD 通过激活 AMPK 信号通路，抑制下游 SREBF1/SCD1 通路并激活自噬，减少肝脏脂质积累。 AKF-PD 通过抑制巨噬细胞浸润和 NLRP3 炎性小体改善肝脏 ...

1 Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Department of Basic Medicine, Gannan Medical University, Ganzhou, China 2 Department ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...