本期推荐：胰腺癌治疗面临代谢重编程与治疗抵抗的挑战。江苏大学团队发现m 6 A阅读蛋白IGF2BP2通过稳定SLC1A5 mRNA促进谷氨酰胺代谢，激活mTORC1通路驱动肿瘤进展。靶向IGF2BP2可增强放化疗敏感性，为胰腺癌治疗提供新策略。该研究发表于《Cancer Cell International ...

CY5-L-Glutamine 可用于 研究谷氨酰胺跨膜转运蛋白（如 SLC1A5, SLC38A1），分析 细胞对氨基酸的摄取机制。 通过 荧光显微镜、流式细胞术 观察 CY5-谷氨酰胺的摄取情况。 代谢示踪 在 癌细胞代谢研究 中，CY5-L-Glutamine 可用于 分析谷氨酰胺在三羧酸循环（TCA）中的代谢 ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial ...

1 Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China 2 Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China Collagen ...

研究表明，甲状腺癌细胞中谷氨酰胺转运体 SLC1A5 表达上调，促进谷氨酰胺摄取。此外，丝氨酸、甘氨酸和脯氨酸等氨基酸代谢也与甲状腺癌的进展密切相关，它们参与了一碳代谢、氧化还原平衡维持和肿瘤的转移过程。 TCA 循环与线粒体：线粒体是细胞的能量 ...

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2, mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially overlapping that of Prader-Willi ...