2025年3月成都的这场学术盛会，折射出中国每年新增4.5万例神经内分泌肿瘤患者的诊疗困境。作为发病率年增长超8%的'隐形杀手'，这类肿瘤因异质性强、诊断滞后等特点，五年生存率长期徘徊在40%-60%之间。当AI诊断系统在肺癌领域准确率突破95%时，NEN的误诊率仍高达38%，这种反差暴露出精准诊疗体系的建构已刻不容缓。本次论坛汇聚的23个学科专家，正试图用跨界思维破解这一医学难题。

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The genomic landscape of hereditary SDHB-mutant pheochromocytomas (PC) and paragangliomas (PG) remains to be explored. Here, the authors perform multiomic analysis on 94 tumours from 79 patients ...

蛋白质组学鉴定出966个差异表达蛋白(DEPs)，其中663个下调。GO分析显示DEPs富集于ATP合成耦联电子传递(如SDHA、SDHB、UQCRC1)、鞭毛运动(如ENO4、SPAG6)和类固醇代谢(如APOB、FXN)。KEGG通路提示PI3K-Akt和钙信号通路可能参与调控。 关键蛋白互作网络 PPI分析发现，ENO4与ATP ...

Braze (Nasdaq: BRZE) the leading customer engagement platform that empowers brands to Be Absolutely Engaging™, today announced results for its fiscal year ended January 31, 2025.

SDHB, succinate dehydrogenase complex iron sulfur subunit B; TAX1BP1, Tax1 binding protein 1; TCA, tricarboxylic acid cycle; TFAM, mitochondrial transcription factor A; tMCAO, transient middle ...

The patient underwent a gastroscopy, which revealed a large-ulcerated tumor on the greater gastric curvature. Histological analysis showed a poorly differentiated SDHB-deficient GIST with PDL1 ...

State investigators uncovered more than $2 million in welfare fraud in the most recent quarter, according to State Auditor Diana DiZoglio’s office.

肾上腺皮质癌的隐蔽性远超公众想象。这种起源于肾上腺皮质的恶性肿瘤，早期症状往往被误认为亚健康状态。美国内分泌学会研究发现，67%的肾上腺皮质癌患者首诊时已出现转移。其典型症状如向心性肥胖、皮肤紫纹等，极易与代谢综合征混淆。更值得注意的是，该病发病年龄集中在30-50岁，正值人生黄金期的患者常因工作压力忽视身体信号，导致确诊即晚期的悲剧反复上演。

Clinical Impact and Genomic Features of Human Epidermal Growth Factor Receptor 2–Low Tumors in BRCA1/2-Mutated Triple-Negative Breast Cancer Of the 103 patients with CPS recommended for WB-MRI ...