宁波大学附属第一医院的研究人员勇挑重担，开展了一项意义重大的研究。他们将目光聚焦于信号转导与转录激活因子（STAT）家族，这个家族在细胞周期、免疫反应和肿瘤发展过程中发挥着至关重要的作用，可其在结直肠癌中的功能和表达情况此前却并不明确。研究人员经过深入探索，发现 STAT3 和 STAT5B ...

(b) FISH:RARα break-apart probe: 1F1 G signal indicating deletion of areas distal to 3of RARα gene (interphase nuclei). (c) Integrative Genomics Viewer (IGV v2.11.2) showing STAT5B::RARα gene fusion ...

It is hypothesised that the growth hormone (GH) target STAT5b maintains mucosal barrier integrity by promoting CEC survival and inhibiting NF-κB activation. Methods: The GH effect upon mucosal injury ...

考虑为 T-LGL 可能性大 ，请结合临床、形态及 STAT3、 STAT5 检查结果除外T-LGLL。 10、脱氧核糖核酸测序-STAT5B（Exon16） 、脱氧核糖核酸测序- STAT3（Exon21）脱氧核糖核酸测序-STAT3（Exon19-20） ：回示正常。 PART.3 2、多参数流式细胞术检测淋巴细胞免疫表型具备特征性的 ...

Acquisition of the constitutively active Janus kinase 2 (JAK2)V617F mutation occurs in almost all patients with polycythaemia vera (PV) and in a significant number of patients with essential ...

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

并且MPL-L基因在三种组织中跟随MPL-L+ T细胞的轨迹呈现出明显的上升趋势（图7 i）。通过MAGIC表达相关性分析证实了MPL-L表达与其下游基因JAK2和STAT5B在MPL-L+ T细胞中的正相关性（图7j-k）。 本研究通过单细胞转录组测序，在无颌脊椎动物七鳃鳗中发现了一种独特的T ...

Regulatory T cells (Treg) are essential for immune balance, preventing overreactive responses and autoimmunity. Although traditionally characterized as CD4+CD25+CD127 low FoxP3 hi, recent research has ...

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy of anticancer treatments in cancer. It affects all stages of cancer, ...

lgp130 模型虽能模拟 STAT3 激活和慢性细胞因子刺激，但更像是自身免疫和炎症模型，而非白血病模型。针对 STAT5B 的模型，会引发多种不同的疾病，不能很好地体现 T-LGLL 的特征。基于 STAT5A 的模型，因在 T-LGLL 患者中未发现 STAT5A 突变，其适用性受限。CRISPR/Cas9 介 ...

This is an important study that characterizes a surprising interaction between two different cytokine/hormone receptors using nanoscale resolution (dSTORM) microscopy. The study provides solid ...