日前，研究团队在《自然》旗下的Nature Communications发表论文，通过多维度解析鞘氨醇-1-磷酸受体1（S1PR1）受体偏向性激活机制，阐明了S1PR1激动剂 ...

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Importantly, decreased expression of the gene encoding KLF2 or its target S1pr1, reduced the ability of mice to develop ...

The recent report that the sphingosine-1-phosphate receptor 1 (S1PR1) is a high-affinity receptor for a related epoxy lipid prompted us to ask, “Why has the putative EET receptor not been discovered ...

在探究自然杀伤（NK）细胞抗肿瘤机制的征程中，研究人员聚焦 NK 细胞脱颗粒的内在调节因子。经刺激人原代血源性 NK 细胞并测序分析，发现 CXCR4 和 S1PR5 为关键负调控基因。这一成果为肿瘤微环境中增强 NK 细胞杀伤能力提供了新方向。 在人体的免疫系统中 ...

S1PR1, Sphingosine-1-phosphate Receptor 1; EOMES, Eomesodermin; HOBIT, Homeobox Protein Hox-11-Like; BLIMP-1, B Lymphocyte Induced Maturation Protein 1; VCAM-1, vascular cell adhesion molecule-1.).

Importantly, decreased expression of the gene encoding KLF2 or its target S1pr1, reduced the ability of mice to develop resistance to flu. “Our findings show that the migration program of plasma ...

Their findings revealed upregulation of ICOS and S1PR1, suggesting a persistent pro-inflammatory state (Figure 1A), as these genes are involved in immune cell survival and signaling. They also ...