Rapamycin, a drug typically used to prevent organ rejection in transplant patients, has gained attention recently for its potential anti-aging properties. Research suggests that rapamycin can extend ...

This study determined whether pharmacological inhibition of the mammalian target of rapamycin (mTOR), a key inhibitor of autophagy, has disease-modifying activity in experimental osteoarthritis.

Researchers conducted a retrospective study to evaluate if 11-oxygenated androgens, like 11-ketotestosterone (11KT), predict the onset of castration-resistant prostate cancer (CRPC). They found that ...

Here we used the well-established dimerization of the FKBP12 protein and FRB domain by rapamycin to bring the target protein WDR5 into proximity with candidate E3 ligases. Strikingly, this ...

The New York version of an art carnival has lost the anarchic charge it was born with almost four decades ago (though a new act may thrill the kids). By Blake Gopnik In her cityscapes, a ...

The Kerala High Court has held that when proceedings under Section 107 of the CrPC have already been initiated against an individual, the competent authority must assess whether it was necessary ...

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Historically, patients diagnosed with castration-resistant prostate cancer (CRPC) have had poor survival rates. In recent years there have been significant advances in the treatment of CRPC.

'Star Wars'' sneaky rebel spy returns to conclude his hero's journey this spring. "Andor" is coming back in just five months. The sensational "Rogue One: A Star Wars Story" spinoff series debuted ...

The discovery that peptides from myelin proteins in the brain help the immune system’s T cells to suppress autoimmunity could pave the way to developing therapies for inflammatory brain diseases ...