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12 天
综述:针对阿霉素诱导的心脏毒性靶向调控细胞死亡的天然产物
研究表明,抑制 RIP1 介导的坏死性凋亡可减轻 ADR 诱导的心脏毒性 ... 此外,白藜芦醇还可通过上调 p62-Nrf2/HO-1,阻断线粒体 ROS 的过度产生和铁死亡。姜黄素(curcumin)是姜黄中的重要多酚,可降低 ADR 诱导的细胞凋亡,调节 14-3-3γ 蛋白,改善线粒体功能;同时 ...
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