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多组学特征揭示伊立替康关键核心调节因子 FSTL3 促进结直肠癌进展并 ...
单细胞分析显示,FSTL3 和 TMEM98 主要在结直肠癌干细胞中表达。通过随机森林分析确定了 FSTL3 是伊立替康相关的核心风险调节因子,它与一些铁死亡调节因子(如 GPX4、HSPB1 和 RGS4)以及相关代谢途径(如脂质氧化和 ROS 代谢)显著相关。在体外实验中,伊立替康 ...
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