【 不久前，48岁的欧女士因“消化不良”到医院就诊，经检查确诊为卵巢癌，且已经全腹扩散，并转移至锁骨上淋巴结，属于晚期，而她的姐姐也是因为卵巢癌于两年前去世。为什么姐妹俩都难逃卵巢癌“魔咒”呢？欧女士的基因检测结果给出了答案——BRCA1胚系突变。】 ...

Background Low-impact genetic variants identified in population-based genetic studies are not routinely measured as part of clinical genetic testing in familial breast cancer (BC). We studied the ...

This includes PALB2, RAD51B, RAD51C, RAD51D, RAD54L, and BRIP1 (none of these genes have EMA approval). Switching to PARP inhibitor combination therapy, there is preclinical rationale for a combined ...