此前研究表明，ERα 能通过调节 PTPRO、P53、TNF 等基因，抑制 Wnt/β - catenin 信号通路并激活 Hippo 信号通路，从而抑制 HCC 的发生发展 。但是，ERα 在 HCC 肿瘤微环境中的详细功能却一直模糊不清。同时，巨噬细胞（Mφ）作为肝脏中比例最高的免疫细胞群体，在维持 ...

Background: Wilms tumor (WT) is the most common childhood renal malignancy, with recurrence linked to poor prognosis. Identifying the molecular features of tumor phenotypes that drive recurrence and ...

Operational tolerance after kidney transplantation is defined as stable graft acceptance without the need for immunosuppression therapy. However, it is not clear which cellular and molecular pathways ...