Lipid anchors on nerve cell membranes stabilize prion protein folding, inhibiting aggregation. Membrane-anchored proteins clump only when exposed to pre-formed protein aggregates, simulating ...

3D reconstruction of a microscope image: red is the membrane and green is clumped prion protein. In order to gain new insights into the underlying processes, the researchers have developed new ...

A research team has now used new in vitro and cell culture models to show that a lipid anchor on the outer membrane of nerve cells inhibits the aggregation of the prion protein. Researchers have ...

"What's interesting is that the clumping of membrane-anchored PrP could be induced by pre-formed protein aggregates," says Tatzelt. "This is a mechanism that might play a role in infectious prion ...

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure itself. This lays the groundwork for a ...

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool. The prion hypothesis remains ...

Protein aggregation is typical of neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt ...

Dr. Yee's group published the first crystal structure of the human prion protein, whose conformational transformation to a pathogenic form is believed to be important in an intriguing family of ...

The treatment, ... A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. A new study of prion diseases ...

Some of these proteins can also convert normal versions into their own twisted images, thus spreading the disease throughout the brain. The classic examples are prion diseases like mad cow disease and ...