Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...

在 HSV-1 的裂解感染过程中，部分病毒立即早期（IE）基因，如 ICP0、ICP4、ICP22 和 ICP27，会劫持宿主基因表达机制。这使得 RNA 聚合酶 II（Pol II）从宿主染色质转移到病毒基因组，进而导致宿主转录普遍关闭。其中，ICP4 在招募 Pol II 至病毒复制区起关键作用 ...

为探究 DNA 结合蛋白的可逆糖基化对转录的作用，研究人员开展 O-GlcNAc 相关研究，揭示其与 RNA Pol II 的相互作用，意义重大。 在生命科学的微观世界里，细胞的各项活动都受到精细的调控，其中转录过程更是像一场复杂而有序的交响乐，众多分子参与其中 ...

尽管我们对转录和剪接作为两个独立过程的理解有所进展，但细胞背景下共转录剪接的分子机制仍有待阐明。我们之前已经确定了转录Pol II-U1 snRNP复合物的结构，该复合物提供了一个模型，该模型显示了距离很远的内含子末端如何功能性地配对以进行剪接。

New Mangalore Port achieves record cargo handling, reports profit growth despite challenges, implements upgrades, and ...

Despite a 32.76% drop in the past 30 days, analysts foresee a potential 0.47% price increase for POL in March. Expected trading prices range between $0.192 and $0.225, with an average of $0.206.

The New Mangalore Port has set a new all-time record by handling 46.01 million tonne of cargo in 2024-25 when the port celebrates its golden jubilee year.

Pol Taburet’s latest exhibition, Oh, If I Only Could Listen, signals a compelling shift in his artistic approach, exploring the interplay between violence and stillness, tension and detachment.

Consequently, numerous analysts eagerly anticipate the future valuation of its native cryptocurrency, POL. This raises the question: Can POL’s price reach $10? This forecast for Polygon’s price ...

Researchers have long struggled to understand how cancer cells hijack one of these proteins -- called polymerase theta (Pol-theta) -- for their own survival. But scientists have now captured the ...