Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with ...

结果发现，ISG15 处理的成纤维细胞中，糖酵解途径相关基因显著富集，糖酵解相关基因（如 GAPDHS、PFKFB1、LDHC）的表达上调，葡萄糖消耗和乳酸生成增加。使用糖酵解抑制剂 2 - 脱氧 - D - 葡萄糖（2 - DG）处理后，ISG15 介导的乳酸生成和细胞迁移受到抑制，这表明 ...

The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as ...