The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK ...

pRb 是一种重要的肿瘤抑制蛋白，正常情况下，pRb 与转录因子 E2F 结合，抑制细胞周期相关基因的转录，阻止细胞进入 S 期 。HPV E7 蛋白（49 - 57）片段能够与 pRb 结合，干扰 pRb - E2F 复合物的形成，释放 E2F，从而激活细胞周期相关基因的转录，促进细胞增殖 ...

and resulting in the E2F-mediated stimulation of genes involved in the G1 → S transition. The E7 proteins of high-and low-risk HPV strains share a specific amino acid difference in their pRb ...

He stresses that the safety and security of tenants remain a top priority. Naleba says an audit was conducted at the PRB Charleston Street and Mead Road estates, both ageing properties established in ...

有很多朋友好奇我们在研究前列腺癌时，如何使用或者构建动物模型。今天就和大家介绍一种我们常用的小鼠模型TRAMP小鼠，通过这种鼠了解一些特殊的前列腺癌。前列腺癌常用小鼠模型常见模型主要包括异种移植模型和基因小鼠模型。异种移植模型将人前列腺癌细胞或患者来 ...

Nasdaq Dividend History provides straightforward stock’s historical dividends data. Dividend payout record can be used to gauge the company's long-term performance when analyzing individual ...

The Public Rental Board has received over 200 applications seeking an affordable housing opportunity. It says these applications are from the first three months of this year. General Manager Timoci ...

MiR-146b has been identified as being overexpressed in human bladder cancer (BCa) and implicated in promoting cancer cell invasion. However, its specific involvement in BCa cell growth remains unclear ...

To stop MB cell proliferation, the same two steps might be required: going into G0 arrest and then differentiating. MB cultures treated with CDK4/6 inhibitor (1 uM Palbociclib) to drive them into G0 ...

此外，敲低 POLD2 会减弱 MYC 表达，这可能会降低细胞周期蛋白依赖性激酶 4 和 6、磷酸化视网膜母细胞瘤蛋白（pRb）、视网膜母细胞瘤蛋白（Rb）和 E2F 转录因子 1（E2F1）的表达。在 373 例完全切除的肺腺癌患者中，高 POLD2 表达（n = 146，39.3%）的患者吸烟史、晚期 ...