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mPEG-NMe3+Br- 甲氧基聚乙二醇-三甲基溴化铵种基于甲氧基聚乙二醇(mPEG ...
阳离子化的PEG能够与带负电荷的DNA或RNA形成复合物,用于基因递送系统。 通过静电相互作用,mPEG-NMe3⁺Br⁻可以包裹核酸,形成纳米颗粒,保护核酸免受酶降解,并促进其进入细胞。 (2)细胞膜靶向 阳离子基团可以与细胞膜上的负电荷成分(如磷脂)发生静电 ...
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