Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

在一项新的研究中，来自密歇根大学、丹娜法伯癌症研究院和维也纳医科大学的研究人员发现PDGFRA基因发生DNA改变的高分级胶质瘤肿瘤细胞对药物阿伐替尼（avapritinib）有反应，其中该药物已被美国食品药品管理局（FDA）批准用于治疗PDGFRA外 ...

A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food and Drug ...

Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10–15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have a different pathogenesis, ...

Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas.

文章中说，血小板源性生长因子受体α（PDGFRA）对肿瘤的发生至关重要，在高级别胶质瘤（HGG）中经常发生基因组改变。在包含 261 例儿童高级别胶质瘤的综合数据集中，研究者检测到 15% 的病例存在 PDGFRA 突变和/或扩增，这表明 PDGFRA 可作为治疗靶点。

A new therapy offers hope for treating pediatric brain tumors, targeting cancer cells while minimizing side effects for young ...

研究从肿瘤微环境的角度出发，强调了基质细胞与癌细胞之间的动态相互作用在肿瘤进展中的重要性。通过多维蛋白质组学分析，研究揭示了细胞间信号传导的复杂性，并提出了新的理论框架，即通过分析细胞间信号传导网络来理解肿瘤的生物学行为和寻找新的治疗靶点。