Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas.

研究从肿瘤微环境的角度出发，强调了基质细胞与癌细胞之间的动态相互作用在肿瘤进展中的重要性。通过多维蛋白质组学分析，研究揭示了细胞间信号传导的复杂性，并提出了新的理论框架，即通过分析细胞间信号传导网络来理解肿瘤的生物学行为和寻找新的治疗靶点。

Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas. Not only ...

小儿高级别胶质瘤，尤其是H3K27M弥漫性中线胶质瘤（DMG），是侵袭性恶性脑肿瘤，预后较差。先前的研究表明，血小板衍生生长因子受体α (PDGFRA)似乎在成人和儿童高级别胶质瘤的发病机制中起着多方面的作用。PDGFRA的基因改变不仅在儿童高级别胶质瘤患者中很 ...

Blueprint Medicines' strong pipeline and Ayvakit growth make it promising. Read why BPMC stock is rated "Hold" due to high ...

Mar. 13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States ...

13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food ...

是时候重新展露成长锋芒了。过去两年半，基石药业在财务端度过颠簸期，已经解决生存问题。2024年财务业绩同比大幅改善，接近盈亏平衡；管线1.0商业化产品实现可持续盈利，舒格利单抗（PD-L1抑制剂）、普拉替尼（RET抑制剂）、阿伐替尼（KIT/PDGFRA抑制剂）将提供稳定现金流和足够安全垫。站在坚实的岸上，下一步即是在研发 ...