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你知道吗？肺动脉高压（PH）是一种严重的慢性疾病，其特点是肺血管逐渐狭窄，最终导致右心衰竭。尽管医学界在PH的治疗上不断取得进展，但其病理机制仍然存在许多未解之谜，尤其是血小板在其中的作用一直备受关注。最近，王涛教授和洪城教授团队的一项研究为我们揭开了这一机制的重要一环，为PH的精准治疗提供了新的方向。

肺动脉高压是一种严重的疾病，表现为肺血管重塑和右心衰竭，致死率居高不下。尽管临床观察到PH患者的血小板减轻及相关参数与病情严重程度相关，但血小板在此病理状态下的角色尚未被充分理解。以往研究提醒我们，血小板可能通过多种方式影响肺血管的结构，特别是释放生长因子（如PDGF-BB）或参与微血栓形成。近期的新发现则进一步指明，血小板的失常功能很可能是导致PH进展的关键因素。

Various cell lineages, such as osteoblast lineage cells, vascular endothelial cells (ECs), and osteoclasts, contribute to the formation of type H vessels by secreting VEGF, SLIT3, and PDGF-BB.

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...

采用 ELISA 方法对组织匀浆（AC-H）、球磨粉（AC-P）和冻干粉（AC-L）这三种样本中的转化生长因子 -β 1 （TGF-β 1 ）、碱性成纤维细胞生长因子（bFGF）、血小板衍生生长因子 - BB（PDGF-BB）、血管内皮生长因子 - A（VEGF-A）和表皮生长因子（EGF）进行定量分析 ...

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Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...

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