Ovarian cancer treatment is complex, and there are many strategies for attacking the disease. One group of treatments are so-called PARP inhibitors. PARP stands for poly (ADP-ribose) polymerase. PARP ...

A team of staff from the Faculty of Biology of Moscow State University and the Belozersky Research Institute of Physico-Chemical Biology of Moscow State University has proposed a convenient method for ...

Mutations in BRCA2 — a gene known to repair damaged DNA and suppress tumor formation — can predict an individuals' predisposition to develop breast cancer, ovarian, prostate, pancreatic, and other ...

Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation—can predict an individual's predisposition ...

This changes how cells express their genes, especially a gene called EME1. The researchers were able to show that this change in EME1 made cancer cells with faults in BRCA1(but not BRCA2) become ...

Results from the PAOLA-1 study showed that the PARP inhibitor drug significantly increased the time women lived without disease progression when added to the standard-of-care, Genentech’s ...

研究人员为探究 PARP 家族致病机制，利用 TurboID 技术识别其互作蛋白，为相关疾病治疗提供依据。 在生命的微观世界里，细胞活动的调控机制如同精密的时钟，每一个环节都至关重要。聚（ADP - 核糖）聚合酶（PARP）家族便是这个时钟里不可或缺的 “零件 ...

Cash and cash receivable balance of $20.9 million as of December 31, 2024, expected to fund operations, including clinical activities ...

The common side effects of all PARP inhibitors include: nausea, vomiting, fatigue, upset stomach and bone marrow issues. Each of three types of PARP inhibitors–Niraparib, Rucaparib, and Olaparib–have ...