Out of these, 2480 genes are common between E2F4-p53 Re-ChIP seq and E2F4 ChIP and are not part of the Fischer DREAM target list. In future, these 2480 genes may be considered as DREAM complex targets ...

有很多朋友好奇我们在研究前列腺癌时，如何使用或者构建动物模型。今天就和大家介绍一种我们常用的小鼠模型TRAMP小鼠，通过这种鼠了解一些特殊的前列腺癌。前列腺癌常用小鼠模型常见模型主要包括异种移植模型和基因小鼠模型。异种移植模型将人前列腺癌细胞或患者来 ...

p53 normally functions to gauge DNA damage, halt cell-cycle, and activate the apoptotic pathway. The E7 viral oncoprotein has been shown to bind to retinoblastoma protein (Rb), releasing E2F from ...

为探究衰老细胞中基因组不稳定与炎症的关联，研究人员聚焦 p53，发现其可抑制 CCF 积累及炎症，或为衰老相关疾病治疗提供新靶点。 在生命的长河中，衰老就像一个无法避免的 “关卡”，它带来了身体机能的衰退，还让我们更容易患上各种疾病。随着年龄的 ...

Optimizing Radiotherapy Timing for Nasopharyngeal Carcinoma: The Impact of Radiation Scheduling on Survival Eligible patients had AKT1 E17K–mutated metastatic tumors that progressed with standard ...

KEGG pathway analysis showed that KIF18B was mainly involved in the malignant progression of glioma through P53 and other signaling pathways. GSEA analysis showed that the high expression group of ...

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...