本研究结果揭示了神经酰胺通过直接结合CYSLTR2和P2RY6受体启动跨膜Gq和炎症体信号传导的结构和分子机制，阻断这些信号传导可能为治疗动脉粥样硬化相关疾病提供新的治疗思路，为开发新的治疗策略提供了理论依据。

In mice, deletion of Cysltr2 and P2ry6 alleviated ceramide-mediated aggravation of high-fat diet-induced atherosclerosis. In addition, CYSLTR2/P2RY6 deficiency or treatment with a CYSLTR2 and/or a ...