New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in ...

He died ~16 months after the onset of symptoms. Genetic testing identified a heterozygous two base pair deletion in the TBK1 gene (NM_013254.3:c.2099_2100del; p.(Val700Glyfs*2); online supplementary ...

为探究 E3 泛素连接酶自身的翻译后修饰和稳定性，研究人员开展了关于 USP43 与 RNF2 关系的研究。结果发现 USP43 能稳定 RNF2，二者通过调控 TBK1 泛素化和降解影响抗病毒先天免疫，揭示了新的免疫调控机制。 摘要：E3 泛素连接酶通常调节底物蛋白的泛素化和降解 ...

为探究 TBK1/IKKε 缺失时细胞死亡途径选择问题，研究发现其可限制 RIPK1 和 NLRP3 死亡通路，意义重大。 在细胞的生命活动中，细胞死亡与炎症的调控一直是生命科学领域的重要研究方向。TBK1（TANK 结合激酶 1）和 IKKε（核因子 κB 抑制因子激酶亚基 ε）这两种激酶 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

DAX Futures 22441.00-238.00-1.05% ...

Commissions do not affect our editors' opinions or evaluations. The price-to-earnings ratio, or P/E ratio, helps you compare the price of a company’s stock to the earnings the company generates.

Introduction: Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration, and even death in piglets, resulting in serious economic losses to ...