New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in ...

为探究 E3 泛素连接酶自身的翻译后修饰和稳定性，研究人员开展了关于 USP43 与 RNF2 关系的研究。结果发现 USP43 能稳定 RNF2，二者通过调控 TBK1 泛素化和降解影响抗病毒先天免疫，揭示了新的免疫调控机制。 摘要：E3 泛素连接酶通常调节底物蛋白的泛素化和降解 ...

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The number of melanomas diagnosed per person at the 12-month follow-up did not differ significantly between the groups (0.08 and 0.16 in the intervention and control groups, respectively ...

Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease pathology. Here, the authors find p-tau 181 and 217 are elevated in serum and ...

进一步研究发现，UGT1A1 不影响 TBK1 与 IRF3 的相互作用，且能在 Tbk1-/-小鼠胚胎成纤维细胞 ... 发现 UCB 和 CB 均显著下调 IFN 诱导的 p-STAT1 水平，且 UCB 抑制作用更强，20 μM UCB 可显著抑制多种细胞中 IFN-I 诱导的 STAT1 磷酸化，且该浓度 UCB 不显著导致细胞死亡。

Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging. Endocrine disruption in Crohn's disease ...