Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

c) PDX1/IPF1-MODY (MODY 4): PDX1 gene (13q12.2), PDX1 protein. Crucial for pancreatic/β-cell development and insulin gene expression. d) NEUROD1 MODY (MODY 6): NEUROD1 gene (2q32), NeuroD1 protein.

之后，通过腹腔注射他莫昔芬诱导 Ascl1-TdTomato 表达。在阿霉素处理 2 周后，对小鼠进行安乐死并取材，利用免疫组织化学技术，使用针对不同神经发生阶段标记物（如 Sox2、NeuroD1 和 GFAP）的抗体，结合抗红色荧光蛋白（RFP）抗体，来检测 Ascl1 阳性细胞。最后 ...

肿瘤-神经交互作用作为近年肿瘤研究的前沿领域，其探索逐步从中枢神经系统（CNS）向周围神经系统（PNS）延伸。现有研究表明，肿瘤细胞可通过外周神经元调控实现生存优势，但 既往研究多集中于胶质瘤等CNS肿瘤与神经元的互作，而对PNS-肿瘤特别是胃癌领域的解析仍存在着诸多空白 。

Gestational diabetes is a major public health problem because of its prevalence, its associated complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin ...

Purpose: The aim of this study was to investigate the prognostic value of the abnormal expression of anaplastic lymphoma kinase (ALK) protein in patients with small cell lung cancer (SCLC) based on ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The lack of regeneration in the human central ...