本研究针对神经发育和再生中双亮氨酸拉链激酶（DLK）调控神经突生长的分子机制尚不明确的问题，通过构建DLK稳定敲低的Neuro-2a细胞模型，结合定量磷酸化蛋白质组学（iTRAQ）和靶向质谱（PRM）技术，发现DLK通过调控中间丝蛋白巢蛋白（nestin）的磷酸化及表达 ...

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On the protein level, in 2D culture, after 7 days, immunofluorescence staining revealed significant changes in marker expression (Figures 5a, c). The early neural marker NESTIN showed a significant ...

2025 年 2 月，中国科学院上海高等研究院、广东省智能科学与技术研究院张旭院士和复旦大学附属华山医院毛颖团队在Cell Discovery 上发表了题为「Human DDIT4L intron retention contributes to ...

After removing the blocking solution, primary antibodies were added. The primary antibodies used in this study for cell immunofluorescence included Pkd2l1 (AB9084, 1:700, Merck Millipore, MA, United ...

Learn how nanoparticles cross the blood-brain barrier (BBB) and explore their potential in treating neurological disorders ...

为解决脊髓损伤修复难题，研究人员开展丹参酮 IIA 磺酸钠（STS）对脊髓损伤作用研究，发现其可促进内源性神经干细胞（ENSCs）增殖分化，通过抑制 Notch 通路改善损伤修复，为 SCI 治疗提供新思路。

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同时，神经干细胞的标记物Nestin表达上升，MGCs的标记物谷氨酰胺合成酶（GS）表达下降，这一系列变化表明MGCs发生了去分化。深入研究发现 ...

CAN-3110 exhibited potent, tumor-specific cytotoxicity in human and murine melanoma cell lines with varied CDKN2A pathway alterations and Nestin expression. In vivo mouse studies showed dose ...