It has been previously shown that the nuclear receptor subfamily 4 group A (NR4A) plays an important role in cardiovascular ...

Although NR4A (the nuclear receptor subfamily 4 group A) plays an important role in cardiovascular pathophysiology, the expression profile and biological function of NR4A member 1 (NR4A1) in platelets ...

你是否了解空气中微小的纳米塑料颗粒对健康的潜在威胁？ 天津医科大学第二院泌尿外科研究所的一项最新研究揭示了纳米塑料通过吸入机体引发对肾脏的毒性作用 。 该研究利用小鼠模型和人体肾脏类器官，深入探究了纳米塑料如何在体内分布、积累，并引发肾脏损伤。 结果令人警醒！想要了解纳米塑料如何悄无声息地影响我们的健康吗？快来阅读这篇文章，一同揭开纳米塑料与肾脏健康之间的神秘面纱！

Nuclear receptor 4a1 (Nr4a1), a member of the nuclear orphan receptor family, has been described to regulate inflammation and immune development in a cell type-specific manner, but its role in ...

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843 , United States ...

头颈鳞癌（HNSCC）中免疫抑制性Treg亚群的作用机制尚不明确。上海交通大学医学院团队通过单细胞RNA测序（scRNA-seq）发现IL1R2 + Treg亚群显著富集于肿瘤组织，其通过NR4A1核转位上调CTLA4表达，促进免疫逃逸。研究证实血清可溶性IL1R2（sIL1R2）具有诊断价值 ...

研究结论和讨论部分指出，该研究通过转录组和功能分析，深入了解了人类房颤相关的基因、表达模块和细胞群体。研究结果为房颤的长期结构重塑和心律失常基质的形成提供了转录组和机制方面的见解，确定的多个差异表达基因可作为房颤治疗的潜在靶点。此外，研究还揭示了性别差异在房颤发病机制中的作用，为进一步研究房颤的性别特异性治疗提供了方向。然而，该研究也存在一些局限性，如部分模块可能无法准确归因于特定细胞类型、单细胞 ...

Revenues of €9.2 million for the full year of 2024Cash and cash equivalents at €96.6 million as of December 31, 2024 First tranche of up to €348 ...

First tranche of up to €348 million Structured Financing closed with aggregate gross proceeds of €116 million Last patient screened in the NATiV3 Phase 3 clinical trial of lanifibranor in MASH ...