Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat ...
本文揭示胰腺癌(PAAD)细胞通过过表达 NPC1L1 抑制 CD8 + T 细胞功能,NPC1L1 可作为治疗靶点改善 PAAD 免疫治疗效果。 引言 在癌症研究领域,CD8 + T 细胞在抗肿瘤免疫中占据着至关重要的地位,然而肿瘤细胞常常会施展多种免疫抑制策略来逃避 CD8 + T 细胞的监控 ...
The Innovation发表各学科领域高质量的前沿研究和文献综述,领域涉及物理学、化学、材料科学、纳米技术、生物学、医学、地球科学、信息科学、管理学和工程学等,内容涵盖基础研究和应用研究。点击文末“阅读原文”查看本期全部内容(http://www ...
肥胖问题日益严峻,为探究肠道 IL-25 在高脂饮食(HFD)诱导肥胖中的作用,研究人员开展相关研究。结果发现,HFD 小鼠肠道 IL-25 表达降低,过表达 IL-25 可改善代谢。该研究为肥胖相关代谢疾病治疗提供新方向。
Recent research has indicated that several sites within the cholesterol metabolism, such as the NPC1L1 protein, 3-hydroxy-3-methylglutaryl-CoA reductase and 7α- and 27α-hydroxylase, have been ...
3月13日,2025年度3月期ESI(Essential Science Indicators)高被引文章名单正式发布,NRR杂志共有62篇文章入选高被引榜单!这一成绩不仅彰显了NRR杂志在神经再生研究领域的学术影响力,也体现了全球学者对NRR所发表研究成果的高度认可。
Background: Recent studies have suggested a potential association between gastric cancer (GC) and myocardial infarction (MI), with shared pathogenic factors. This study aimed to identify these common ...
Atherosclerosis (AS) is a degenerative and proliferative disease characterised by the deposition of lipid and/or fibrous substances within the intima of arteries. The pathological mechanisms of AS ...
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of type 2 diabetes and cardiovascular disease. These include abdominal obesity ...
以往研究认为胚胎发育过程中的细胞死亡主要以凋亡为主,然而,Hannah K. C. Co 等人的研究揭示了铁死亡在其中的关键作用,并阐明了其传播机制。该研究成果具有开创性价值,提供了全新的视角,因此值得深入评述和讨论。导 ...
Increased hepatic transaminases, myopathy and muscle symptoms, rhabdomyolysis, increased risk of incident diabetes, drug interactions Ezetimibe Inhibition of intestinal NPC1L1—inhibition of ...